Literature summary for 2.6.1.52 extracted from

De Marchi, T.; Timmermans, M.A.; Sieuwerts, A.M.; Smid, M.; Look, M.P.; Grebenchtchikov, N.; Sweep, F.C.G.J.; Smits, J.G.; Magdolen, V.; van Deurzen, C.H.M.; Foekens, J.A.; Umar, A.; Martens, J.W.
Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer (2017), Sci. Rep., 7, 2099 .

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Application

Application	Comment	Organism
diagnostics	phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene PSAT1, quantitative reverse transcriptase PCR enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y617	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	immunohistochemical detection, in breast carcinoma PSAT1 expression is significantly associated with poor grade tumors and local relapse	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
phosphoserine aminotransferase 1	-	Homo sapiens
PSAT1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	analysis of association of PSAT1 protein levels upon tamoxifen treatment and enzyme role in tamoxifen resistance, PSAT1 protein and mRNA levels are significantly associated to poor outcome to tamoxifen treatment. Cytokine and JAK-STAT signaling are associated with PSAT1 expression. Clinical significance of PSAT1 in the gene expression cohort and pathway analysis	Homo sapiens

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Release 2023.1 (January 2023)